To some extent, Overture is already being used in ways that might not be evident. For example, we hosted the Zebrafish Development and Genetics conference last spring: I could see a potential relationship between Overture and UW to bring larger academic/scientific conferences here that are logistically easier to accommodate in Overture than at UW.
Overture's main spaces are too specialized to be used for anything else but concerts, presentations, Broadway, and so on. Some spaces were designed to be used for all sorts of things (the lobby, Promenade Hall & Terrace, etc.). However, just the cost of basic maintenance of the theater spaces alone makes it necessary to put some kind of programming in there, if for nothing else but to help pay for the upkeep.
Oh, and for the record, the alternative plan I've mentioned is not mine....I wish I had it together enough to have come up with a real solution myself
I will post it, though, as soon as I get permission.